Search results for " long chain polyunsaturated fatty acids"

showing 2 items of 2 documents

Efficacy and safety study of an eyelid gel after repeated nocturnal application in healthy contact lens users and non-users

2020

Purpose: To evaluate skin biocompatibility of a nighttime hydrating eyelid gel and possible ocular surface effects in contact lens users (CLU) and non-contact lens users (NCLU). The formulation is registered as a medical device as Tridocosahexaenoine-AOX® (TDHA-AOX) (a concentrated DHA triglyceride), containing also hyaluronic acid (HA). Methods: A prospective, randomized, masked clinical trial was performed with 62 participants of both sexes, aged 20–70 years, split into: (1) CLU (n = 30) and (2) NCLU (n = 32). All participants were instructed to apply a single dose of the moisturizing gel (containing TDHA-AOX and HA) nightly to the upper and inner eyelids of their right eye (RE) only, and…

DHA docosahexaenoic acidNon usersFBUT fluorescein break-up timeALA alpha linolenic acidTDAH-AOX tridocosahexaenoin-antioxidantNCLU non contact lens users0302 clinical medicineLC PUFAs long chain polyunsaturated fatty acidsMedicineCL contact lensesOS ocular surfaceHA hyaluronic acidOSDI ocular surface disease indexDE dry eyeCLU contact lens usersCLDEQ contact lens dry eye questionnaireVEGF vascular endothelial growth factorDocosahexaenoic acidBMC biomicroscopymedicine.anatomical_structureMedicamentosCytokinesOftalmologíaOriginal ArticleBCVA best corrected visual acuitymedicine.medical_specialtyOcular surface dysfunctionCorneal stainingContact LensesHyaluronic acidRE right eyeDEs dry eye syndrome03 medical and health sciencesOphthalmologyHumansAdverse effectbusiness.industryEyelidsEPA eicosapentaenoic acidAnatomía ocularIOP intraocular pressureeye diseasesClinical trialContact lensMOISTURIZING GEL030221 ophthalmology & optometryTearsLE left eyeEyelidsense organsbusiness030217 neurology & neurosurgeryOptometry
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Identification and quantification of phosphatidylcholines containing very-long-chain polyunsaturated fatty acid in bovine and human retina using liqu…

2010

The retina is one of the vertebrate tissues with the highest content in polyunsaturated fatty acids (PUFA). A large proportion of retinal phospholipids, especially those found in photoreceptor membranes, are dipolyunsaturated molecular species. Among them, dipolyunsaturated phosphatidylcholine (PC) molecular species are known to contain very-long-chain polyunsaturated fatty acids (VLC-PUFA) from the n-3 and n-6 series having 24-36 carbon atoms (C24-C36) and four to six double bonds. Recent interest in the role played by VLC-PUFA arose from the findings that a protein called elongation of very-long-chain fatty acids 4 (ELOVL4) is involved in their biosynthesis and that mutations in the ELOVL…

Spectrometry Mass Electrospray IonizationChimie analytiquePhospholipidChromosome DisordersTandem mass spectrometry01 natural sciencesBiochemistryHigh-performance liquid chromatographyRetinaAnalytical Chemistry03 medical and health scienceschemistry.chemical_compoundMacular Degeneration[CHIM.ANAL]Chemical Sciences/Analytical chemistryTandem Mass SpectrometryPhosphatidylcholineQUANTITATIVE ANALYSISAnimalsHumansOxazolesChromatography High Pressure Liquid030304 developmental biologychemistry.chemical_classificationPhosphatidylethanolamine0303 health sciencesVERY LONG CHAIN POLYUNSATURATED FATTY ACIDSChromatography010401 analytical chemistryOrganic ChemistryPHOSPHATIDYLCHOLINES;QUANTITATIVE ANALYSIS;LC-ESI-MS/MS;VERY LONG CHAIN POLYUNSATURATED FATTY ACIDS;RETINAGeneral MedicineLC-ESI-MS/MSeye diseases0104 chemical scienceschemistryBiochemistryDocosahexaenoic acidFatty Acids UnsaturatedPhosphatidylcholines[ CHIM.ANAL ] Chemical Sciences/Analytical chemistrylipids (amino acids peptides and proteins)CattleChromosomes Human Pair 6SphingomyelinPolyunsaturated fatty acidJournal of chromatography. A
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